Triple-Drug Treatment Is Effective for Lymphatic Filariasis Microfilaria Clearance in Samoa

Following the first triple-drug mass drug administration (MDA) for lymphatic filariasis in Samoa 2018, unexpected persistence of microfilaria (Mf) positivity 18 (15%) 121 antigen-positive persons was observed a nationwide household survey 1–2 months later. Of Mf positive persons, 14 reported taking MDA, raising concerns about MDA efficacy. In 2019, 5–6 after 2018 survey, monitored treatment study done to evaluate directly weight-based these individuals. presence and density were assessed before 7 days treatment, using 1 mL membrane filtered venous blood, 60 uL thick blood films on slides prepared from or fingerprick blood. All participants still filters pre-treatment samples, but two negative by slide made same samples. cleared completely day 12 13 followed up, 30 remaining participant. Filtered EDTA samples (to reduce clumping Mf) is preferred over alone improving likelihood detecting estimating their density. The strategy effective at clearing when given taken correct dose.